Li Zhonggang

Hainan Institute of Biotechnology, Haikou, 570206, Hainan, China
Author    Correspondence author
Molecular Plant Breeding, 2025, Vol. 16, No. 6   
Received: 19 Oct., 2025    Accepted: 23 Nov., 2025    Published: 05 Dec., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This study summarizes the epigenetic regulatory mechanisms of grapes under high-temperature stress and discusses the application prospects of CRISPR/dCas9 epigenetic editing, epigenetic marker-assisted breeding, and stress memory in enhancing the stress resistance of grapes. Studies have shown that DNA methylation plays an important role in high-temperature responses. DNA methylation changes regulated by methylase can affect the expression of heat stress-related genes. Reversible regulation of histone modification can also alter the expression levels of heat shock proteins and transcription factors, thereby helping plants adapt to high temperatures. Some mirnas participate in the formation of heat tolerance in grapes by acting on transcription factors and regulating hormone signaling pathways. There exists a complex interaction network among methylation, transcription and protein levels, and genes such as HSFA2 and MBF1c play important roles in this process. This study aims to provide theoretical support and technical references for molecular breeding of heat-tolerant grape varieties and cultivation management in response to climate change.

Grapevine (Vitis vinifera); Heat tolerance; Epigenetic regulation; DNA methylation; Non-coding RNA