Harnessing Synthetic Biology for Functional Metabolite Enhancement in Panax ginseng  

Lianming Zhang
Author    Correspondence author
Plant Gene and Trait, 2025, Vol. 16, No.   
Received: 01 Jan., 1970    Accepted: 01 Jan., 1970    Published: 21 Oct., 2025
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Abstract
This study summarizes the new progress in ginseng metabolism research in recent years, including the analysis of metabolic pathways, the mining of functional genes, and the application of multi-omics in metabolic regulation. It introduces several commonly used methods, such as CRISPR/Cas9 gene editing, metabolic pathway modification, protein engineering, and fermentation condition optimization. These methods not only increased the yield of natural metabolites but also helped create some new derivatives. This study also discussed the current difficulties, such as the complexity of metabolic pathways, insufficient genetic resources, and the challenges when the achievements are industrialized. This study aims to provide ideas and practical references for the molecular improvement and industrial application of ginseng.
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