Baofu Huang , Yuhong Huang , Lianming Zhang

Traditional Chinese Medicine Research Center, Cuixi Academy of Biotechnology, Zhuji, 311800, Zhejiang, China
Author    Correspondence author
Plant Gene and Trait, 2025, Vol. 16, No. 5   doi: 10.5376/pgt.2025.16.0024
Received: 14 Sep., 2025    Accepted: 17 Oct., 2025    Published: 27 Oct., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Huang B.F., Huang Y.H., and Zhang L.M., 2025, Harnessing synthetic biology for functional metabolite enhancement in Panax ginseng, Plant Gene and Trait, 16(5): 225-233 (doi: 10.5376/pgt.2025.16.0024)

 

This study summarizes the new progress in ginseng metabolism research in recent years, including the analysis of metabolic pathways, the mining of functional genes, and the application of multi-omics in metabolic regulation. It introduces several commonly used methods, such as CRISPR/Cas9 gene editing, metabolic pathway modification, protein engineering, and fermentation condition optimization. These methods not only increased the yield of natural metabolites but also helped create some new derivatives. This study also discussed the current difficulties, such as the complexity of metabolic pathways, insufficient genetic resources, and the challenges when the achievements are industrialized. This study aims to provide ideas and practical references for the molecular improvement and industrial application of ginseng.

Ginseng (Panax ginseng); Synthetic biology; Functional metabolites; Ginsenoside; Metabolic engineering