Jianhui  Li

Shouchang Forest Farm, Jiande City, Hangzhou, 311600, Zhejiang, China
Author    Correspondence author
Tree Genetics and Molecular Breeding, 2025, Vol. 15, No. 6   
Received: 31 Oct., 2025    Accepted: 08 Dec., 2025    Published: 20 Dec., 2025

This is an open access article published under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

This study summarizes the main synthesis process of taxol in Taxus chinensis, sorts out the latest research progress of key structural genes such as TS, BAPT, and DBTNBT, and points out that some ring-limiting steps have not been fully resolved. It also sorts out the multilayer regulatory network involving transcription factors such as MYC, ERF, and WRKY. The significant roles of signals such as monosinic acid, ABA, and SA in inducing taxol synthesis were discussed. The potential influences of miRNA and epigenetic modifications in post-transcriptional regulation were introduced. Several key directions for increasing taxol yield were summarized, including the redistribution of metabolic flux, the synergistic enhancement of key enzymes, and the optimization of cell culture systems. This study aims to provide a theoretical basis and technical reference for the efficient biomanufacturing and sustainable resource utilization of taxol in Taxus chinensis.

Taxol; Taxus chinensis; Biosynthetic pathways; Molecular regulatory networks; Metabolic engineering and synthetic biology